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Metabolic Research Compound
5-Amino-1MQ (10mg)
NNMT inhibitor · small-molecule research compound · Research-grade, Australia
In stock · dispatched Australia-wide
View & buy on store →About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a cell-permeable, small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is a methylated quinoline derivative — not a peptide — though it is commonly studied alongside metabolic research peptides and is handled the same way in the laboratory. NNMT catalyses the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, the precursor in the NAD+ salvage pathway.
Within the research community, NNMT inhibition is studied in pre-clinical models for its relationship to the NAD+ salvage pathway, methyl-donor homeostasis, and adipocyte energy metabolism. NNMT expression in white adipose tissue has been a particular focus of published pre-clinical work. 5-Amino-1MQ is supplied by Vital Research Labs strictly as a reference compound for in-vitro laboratory investigation.
Molecular target
- NNMT — nicotinamide N-methyltransferase, the enzyme that methylates nicotinamide to 1-methylnicotinamide using SAM as the methyl donor.
- NAD+ salvage pathway — studied in relation to nicotinamide availability and cellular NAD+ pools.
- Methyl-donor homeostasis — investigated for its relationship to S-adenosylmethionine availability.
Molecular & physical profile
| Compound | 5-Amino-1-methylquinolinium |
|---|---|
| Common name | 5-Amino-1MQ |
| Compound class | Small molecule (quinoline derivative) |
| Molecular target | NNMT (nicotinamide N-methyltransferase) |
| Category | Metabolic |
| CAS Number | 42464-96-0 |
| Form | Lyophilised powder |
| Appearance | White to off-white solid |
| Quantity | 10 mg per vial |
| Purity | N/A — Certificate of Analysis pending |
| Analytical methods | HPLC (purity), mass spectrometry (identity) |
| Solubility (research) | Reconstitutes in bacteriostatic or sterile water |
Batch-specific analytical values will be recorded on the Certificate of Analysis for this batch, which is pending.
Reconstitution & handling
5-Amino-1MQ is supplied as a lyophilised powder. For research handling it is typically reconstituted with bacteriostatic water; the exact volume depends on the concentration a given research protocol calls for. Our reconstitution calculator can be used to work out volumes for a target research concentration. Handle under appropriate laboratory conditions.
Storage & stability
- Powder — store at -20 °C, protected from light and moisture.
- Reconstituted solution — store at 2–8 °C and use within 28 days.
- Handling — keep vials sealed until use; minimise freeze–thaw cycles.
Quality & testing
Every batch supplied by Vital Research Labs is analysed by an independent third-party laboratory, with purity confirmed by analytical testing. Testing for this batch is currently in progress; the Certificate of Analysis will be published in our CoA library once received.
Shipping within Australia
5-Amino-1MQ is dispatched from within Australia to Australian research customers, packaged discreetly and appropriately for a lyophilised research compound. Orders are processed on receipt of payment via bank transfer.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small molecule - a methylated quinoline derivative - rather than a peptide. It is often stocked and studied alongside metabolic research peptides, and is supplied as a powder for reconstitution in the same way.
Is 5-Amino-1MQ available in Australia for research?
Yes. Vital Research Labs supplies research-grade 5-Amino-1MQ (10mg) to Australian research customers, dispatched domestically. It is provided strictly for in-vitro laboratory research and is not for human or veterinary use.
What does NNMT inhibition mean in research?
NNMT (nicotinamide N-methyltransferase) catalyses transfer of a methyl group from S-adenosylmethionine to nicotinamide. In pre-clinical research, inhibiting NNMT is studied for its effects on NAD+ salvage pathway activity and methyl-donor availability.
What purity is your 5-Amino-1MQ?
Testing for this batch is currently in progress. Purity is shown as N/A until the Certificate of Analysis is received, at which point it is published in our CoA library. We do not publish purity figures we cannot evidence.
How should 5-Amino-1MQ be stored?
The powder is stored at -20 degrees C, protected from light and moisture. Once reconstituted for research it is kept at 2-8 degrees C and typically used within 28 days.
Is 5-Amino-1MQ intended for human use?
No. 5-Amino-1MQ (10mg) supplied by Vital Research Labs is intended strictly for in-vitro laboratory research and development. It is not a medicine or therapeutic good and is not for human consumption, veterinary use, or clinical application.